It's well known that taking a drug from inception to launch is a long and costly road.
Despite advances in technology, the situation has not become easier; ROI in pharmaceutical R&D has fallen to its lowest level in a decade (Deloitte, 2019).
Our informatics based approaches can support you at every stage of drug discovery and development, to reduce risks and underpin key decisions with real world evidence.
The CCDC suites have been developed over years of experience working with the top big pharma companies, start-ups and CROs to address the real problems faced throughout drug development.
All of our tools are underpinned by the Cambridge Structural Database (CSD) - a manually curated database of experimentally derived molecular structures. This foundation is key, with pharma industry leaders increasingly recognising the importance of real world evidence in a range of areas including to support regulatory submissions, and to identify new targets or areas of unmet need (Deloitte, 2020).
Case Studies: Pharmaceutical Industry
Explore how our data and software have already made an impact in these case studies from the literature:
Novartis: analysing the metastable polymorph of Loratidine
Here we spotlight a recent publication which shows how CSD data supported a team from Novartis and NanoMEGAS to analyse a metastable form of the antihistamine drug Loratadine.
Bristol Myers-Squibb: discovery of novel inhibitors by fragment based screening
In this paper the team used fragment based screening to identify new inhibitors of factor VIIa, a target in arterial thrombosis, with improved pharmacokinetic properties.
Pfizer: reducing risk in solid form selection of APIs
This paper describes our collaboration with Pfizer, using the healthcheck methodology to select the most stable form across three different active pharmaceutical ingredients.
Browse case studies from across industry and academia here.
What we do
Out software, data and data services can support you at every stage of discovery and development through to final product.
Explore how we can support you at every stage of the pipeline below, or get in touch to test any of our software for yourself.