Bound! | CCDC

Bound! A Protein-Drug Matching Card Game

Bound! is a card game for ages 12 and up where players compete to match the most Drugs to Protein targets. The Bound! card deck features 15 unique pairs of drug and protein structures. There are six different card types comprised of three varieties of target-drug pairing: Bacteria to Antibiotic, Virus to Antiviral and Cancer to Anticancer. The cards can be used to play memory games and can be used as a regular card deck (see rules for more information). There are 60 cards in each deck, with each pair represented twice.

This game is a collaboration between two data resources: The Cambridge Structural Database (CSD), which is curated by the Cambridge Crystallographic Data Centre (CCDC) and RCSB Protein Data Bank (RCSB PDB).

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Ball and Stick depiction of Erythromycin, refcode QIFKEX

Explore the drug cards

Learn more about the drug structures from the CSD

Explore the target and drugs

Learn about the target-drug matches with brief insights into biological aspects.

Paclitaxel is used for treating cancer including ovarian, breast and lung cancer. Paclitaxel binds to the β subunit of tubulin. Inhibitor

Pentostatin is used for the treatment of hairy cell Leukemia. Pentostatin is a transition state inhibitor of adenosine deaminase (ADA).

Learn more about Bacterial protein - Antibiotic pairs including mechanism of action

Erythromycin is used in the treatment of various bacterial infection. Erythromycin stops bacterial growth by inhibiting protein synthesis and translation.

Rifapentine is used in the treatment of tuberculosis. Rifapentine acts via the inhibition of RNA polymerase, leading to a suppression of RNA synthesis and cell death.

Novobiocin is used for the treatment of infections due to staphylococci and other susceptible organisms. Novobiocin binds to DNA gyrase, and inhibits adenosine triphosphatase (ATPase) activity.

Bedaquiline is used in combination with other antibacterials for treating tuberculosis. Bedaquiline inhibits the proton pump of mycobacterial ATP (adenosine 5'-triphosphate) synthase.

Piperacillin is used for the treatment of polymicrobial infections. Piperacillin inhibits bacterial cell wall synthesis.

Learn more about Viral protein - Antiviral drug pairs, including mechanism of action.

Acyclovir was granted FDA approval in 1982. Acyclovir is used to treat herpes simplex, varicella zoster and herpes zoster. Acyclovir causes DNA chain termination via Inhibition.

Nevirapine is used as part of a management regiment for HIV-1 virus infection. Nevirapine binds directly to reverse transcriptase. Inhibitor

Ribavirin is used to treat some forms of Hepatitis C. Ribavirin is reported to have several mechanism of actions that lead to inhibition of viral RNA and protein synthesis. Antagonist, Inhibitor

Raltegravir is an antiretroviral agent used for the treatment of HIV infections in conjunction with other antiretrovirals. Raltegravir inhibits HIV integrase to prevent the viral genome being incorporated into the human genome.

Ritonavir is used as part of a management regiment for HIV-1 virus infection. Ritonavir inhibits the HIV viral proteinase enzyme. Ritonavir is also authorized by the FDA for emergency use in Paxlovid - a COVID-19 antiviral treatment.

Learn more about Cancer protein - Anticancer drug pairs, including mechanism of action.

Sorafenib is used in treating kidney cancer. Sorafenib inhibits Raf kinase.

Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers approved by the FDA in 1977. Tamoxifen competitively inhibits estrogen binding to its receptor. Antagonist, Agonist

Paclitaxel is used for treating cancer including ovarian, breast and lung cancer. Paclitaxel binds to the β subunit of tubulin. Inhibitor

Pentostatin is used for the treatment of hairy cell Leukemia. Pentostatin is a transition state inhibitor of adenosine deaminase (ADA).

Learn more about Bacterial protein - Antibiotic pairs including mechanism of action

Erythromycin is used in the treatment of various bacterial infection. Erythromycin stops bacterial growth by inhibiting protein synthesis and translation.

Rifapentine is used in the treatment of tuberculosis. Rifapentine acts via the inhibition of RNA polymerase, leading to a suppression of RNA synthesis and cell death.