Solid Form Health Check
The Solid Form Health Check provides bespoke analysis of your crystal structure to assess risks and guide your development.
We apply decades of solid-form analysis experience, as well as knowledge derived from our data and the latest software, to understand your solid form.
This risk assessment can complement and guide experimental screening or support the in-licensing of a compound for further development.
Our team performs custom analyses on your API, and you receive a thorough report and executive summary, plus a debrief meeting where our scientists present key findings and answer your questions.
How Does it Work?
- After any required confidentiality agreements, send your CIF file by one of our secure file transfer methods. It is kept strictly confidential and visible only to required staff throughout the analysis.
- Our team begins our bespoke analysis of your structure and communicates early findings to you.
- Over the next week, our team performs a full analysis of your structure, examining inter- and intra-molecular hydrogen bonding, chirality, Z’, polymorphs, and more. Our prepared reports include full analyses, executive summary, and interpretation of the results by our experts.
- We securely return the report to you and then follow up with a debrief meeting to present our key findings and answer any questions you may have about the results. Your structure is then deleted from our files.
Understand the stability and polymorphism risks of your solid form
Allows a deeper understanding of your solid form, with the learnings from over 1 million known structures in the CSD (and your own proprietary structures if available) applied to assess stability, polymorphism, and other risks. Reveals opportunities for intervention. Provides reassurance.
Prioritize and target your experimental work
Complement and guide your experimental work based on the Solid Form Health Check results to help de-risk your solid form. Answer questions like: Are there any warning flags identified for this solid form? Is the crystal packing efficient? Are there accessible void spaces? Is the conformation unusual?
Expert consultancy and analysis
Get straight to the key findings. Use our team’s expertise from hundreds of assessments to customise the analyses, interpret the results and deliver the key recommendations to you.
A rapid preliminary report in about 2 days
Confirm the full suite of tools (CSD-Materials) can be applied before we proceed.
A detailed written report in 8 working days
Understand the complete analysis – with a written report delivered to you – including methodology, analyses, and our expert commentary and interpretation.
Share results with colleagues – the executive summary makes it easy to share results across teams.
Verify the details – following the written report, our team will meet with you to present the results and answer your questions.
Secure data transfer options to suit your security needs
Feel secure partnering with CCDC – we have decades of experience working with top pharmaceutical companies including GSK, Pfizer, Novartis, and AstraZeneca. Your data security is our priority, and we can offer several options to suit your security needs.