Solid Form Health Check
Assess the risk of a more stable solid form appearing, to give you confidence in your regulatory filing, with the bespoke analysis in a CCDC Solid Form Health Check.
We apply decades of solid-form analysis experience, as well as real-world data-driven insights from the latest software, to understand your solid form.
This risk assessment can complement and guide experimental screening or support the in-licensing of a compound for further development.
Our team performs custom analyses on your active pharmaceutical ingredient, and you receive a thorough report, executive summary, plus a debrief meeting where our scientists present key findings and answer your questions.
How Does it Work?
- After any required confidentiality agreements, send your CIF file by one of our secure file transfer methods. It is kept strictly confidential and visible only to required staff throughout the analysis.
- Our team begins our bespoke analysis of your structure and communicates early findings to you.
- Over the next week, our team performs a full analysis of your structure, examining inter- and intra-molecular hydrogen bonding, chirality, Z’, polymorphs, and more. Our prepared reports include full analyses, executive summary, and interpretation of the results by our experts.
- We securely return the report to you and then follow up with a debrief meeting to present our key findings and answer any questions you may have about the results. Your structure is then deleted from our files.
Solid Form Health Check Process
Structure
You select the crystal form and solve the structure.
CDA established with The CCDC.
CIF file securely sent to The CCDC.
Initial Check
2-day initial assessment.
Early findings communicated.
Full Assessment
Full Solid Form Health Check completed.
Analysis of inter- and intra-molecular H-bonding, chirality, Z’, and more.
Results
Full report send to you securely.
Debrief call to answer your questions.
CIF file deleted once report signed off.
Features
Assess your solid form risks
Allows a deeper understanding of your solid form, with the learnings from over 1 million curated structures in the CSD (and your own proprietary structures, if available) applied to assess physical stability, polymorphism, and other risks. Reveals opportunities for intervention. Provides reassurance.
Prioritize and target your experimental work
Complement and guide your experimental work based on the Solid Form Health Check results to help de-risk your solid form. Answer questions like: Are there any warning flags identified for this solid form? Is the crystal packing efficient? Are there accessible void spaces? Is the conformation unusual?
Expert consultancy and analysis
Get straight to the key findings. Use our team’s expertise from hundreds of assessments to customise the analyses, interpret the results, and deliver the key recommendations to you.
A detailed written report in 10 working days
Understand the complete analysis, with a written report delivered to you – including methodology, analyses, and our expert commentary and interpretation.
Executive summary
Quickly understand and share results — the executive summary makes it easy to share results across teams and understand the key findings.
Debrief meeting
Verify the details – following the written report, our team will meet with you to present the results and answer your questions.
Secure data transfer
Feel secure partnering with CCDC – we have decades of experience working with top pharmaceutical companies including GSK, Pfizer, Novartis, and AstraZeneca. Your data security is our priority, and we can offer several options to suit your security needs.
Learn more
FAQs
Your data security is our priority, and we can offer a range of options to suit your needs – including dedicated user accounts, dedicated virtual machines or servers, or your preferred secure file transfer mechanism.
We have decades of experience working with proprietary data from top pharmaceutical companies including GSK, Pfizer, Novartis, and AstraZeneca.
Potentially – let us know what data you have available and of what quality, and then we can advise if the analysis will work.
We have performed Solid Form Health Check analyses with micro-ED, powder diffraction, and neutron diffraction data.
The Solid Form Health Check results can signal if you need to perform additional experimental screening or not and help you to prioritize and target this work. The results complement your experimental work to validate and build confidence in the selected solid form.
The Solid Form Health Check results give you the confidence to proceed with the solid form, or to perform additional experimental screens.
