Welcome to Bound! logo, the protein drug matching game!

Bound! is a card game for ages 12 and up where players compete to match the most Drugs to Protein targets. The Bound! card deck features 15 unique pairs of drug and protein structures. There are six different card types comprised of three varieties of target-drug pairing: Bacteria to Antibiotic, Virus to Antiviral and Cancer to Anticancer. The cards can be used to play memory games and can be used as a regular card deck (see rules for more information). There are 60 cards in each deck, with each pair represented twice. The card types can be identified both by colour and icon. The cards are also numbered for easy splitting when playing memory games that require using half the deck.

 

Bound! logo

This game is a collaboration between two data resources: The Cambridge Structural Database (CSD), which is curated by the Cambridge Crystallographic Data Centre (CCDC) and RCSB Protein Data Bank (RCSB PDB).

To play the game and read the rules, download the pdfs from the right-hand side bar. You can also buy a printed version here (the payment goes directly to the printer, and the cost is not designed to make profit or income for the CCDC or the PDB).

Explore the target and drugs

The drugs structures

To learn more about the drugs from the CSD, click on the button to proceed to the selected drugs structures.

 

 

 

The target-drug matches

In the following you will explore the drug-target matches with brief insights into biological aspects.

  

 Learn more about Bacterial protein-Antibiotic pairs
card logo of pair
Learn more about Viral protein-Antiviral drug pairs
card logo of antiviral-virus pairs
  Learn more about Cancer protein-Anticancer drug pairs
card logo of anticancer-cancer pairs

 

Bacterial Ribosome ← Erythromycin

ribosome-erythromycinErythromycin is used in the treatment of various bacterial infection.
Erythromycin stops bacterial growth by inhibiting protein synthesis and translation.

Herpesvirus DNA polymerase ← Acyclovir

herpesvirus-dna-polymerase-acyclovir
Acyclovir was granted FDA approval in 1982. Acyclovir is used to treat herpes simplex, varicella zoster and herpes zoster. Acyclovir causes DNA chain termination via Inhibition.

B-Raf protein kinase ← Sorafenib

braf-sorafenib
Sorafenib is used in treating kidney cancer. Sorafenib inhibits Raf kinase.

Bacterial RNA polymerase ← Rifapentine

bacterial-rna-polymerase-rifapentine
Rifapentine is used in the treatment of tuberculosis. Rifapentine acts via the inhibition of RNA polymerase, leading to a suppression of RNA synthesis and cell death.

HIV reverse transcriptase ← Nevirapine

hiv-reverse-transcriptase-nevirapine
Nevirapine is used as part of a management regiment for HIV-1 virus infection. Nevirapine binds directly to reverse transcriptase. Inhibitor

Estrogen receptor beta ← Tamoxifen

estrogen-receptor-beta-tamoxifen
Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers approved by the FDA in 1977. Tamoxifen competitively inhibits estrogen binding to its receptor. Antagonist, Agonist

DNA gyrase ← Novobiocin

dna-gyrase-novobiocinNovobiocin is used for the treatment of infections due to staphylococci and other susceptible organisms. Novobiocin binds to DNA gyrase, and inhibits adenosine triphosphatase (ATPase) activity.

RNA-dependent RNA polymerase ← Ribavirin

rna-dependent-rna-polymerase-ribavirinRibavirin is used to treat some forms of Hepatitis C. Ribavirin is reported to have several mechanism of actions that lead to inhibition of viral RNA and protein synthesis. Antagonist, Inhibitor

Microtubule (Tubulin-beta) ← Paclitaxel

microtubule-paclitaxelPaclitaxel is used for treating cancer including ovarian, breast and lung cancer. Paclitaxel binds to the β subunit of tubulin. Inhibitor

Bacterial ATP synthase ← Bedaquiline

bacterial-atp-synthase-bedaquiline
Bedaquiline is used in combination with other antibacterials for treating tuberculosis. Bedaquiline inhibits the proton pump of mycobacterial ATP (adenosine 5'-triphosphate) synthase.

HIV integrase ← Raltegravir

hiv-integrase-raltegravir                                                                                 
Raltegravir is an antiretroviral agent used for the treatment of HIV infections in conjunction with other antiretrovirals. Raltegravir inhibits HIV integrase to prevent the viral genome being incorporated into the human genome.

Histone deacetylase 2 ← Vorinostat

histone-deacetylase-vorinostat
Pentostatin is used for the treatment of hairy cell Leukemia. Pentostatin is a transition state inhibitor of adenosine deaminase (ADA).

Penicillin-binding protein ← Piperacillin

penicillin-binding-protein-piperacillin
Piperacillin is used for the treatment of polymicrobial infections. Piperacillin inhibits bacterial cell wall synthesis.

HIV protease ← Ritonavir

hiv-protease-ritonavir                                                                                             Ritonavir is used as part of a management regiment for HIV-1 virus infection. Ritonavir inhibits the HIV viral proteinase enzyme. Ritonavir is also authorized by the FDA for emergency use in Paxlovid - a COVID-19 antiviral treatment.

Adenosine deaminase ← Pentostatin

adenosine-deaminase-pentostatin
Pentostatin is used for the treatment of hairy cell Leukemia. Pentostatin is a transition state inhibitor of adenosine deaminase (ADA).