There are no hard-coded limits on the size of molecule that DASH can handle.  However, for large structures with many torsion angles (>15) structure solution will be difficult and good data are a necessity.  There is a maximum of 1000 peaks that are allowed in the diffraction pattern.

DASH can handle multicomponent systems: salt, solvates, and other structures with more than one molecule in the asymmetric unit.​

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