Dr Colin Groom has a BSc in biotechnology and a PhD in protein crystallography from the University of Leeds and held postdoctoral appointments at Leeds and at Massey University, New Zealand. Since then, he has worked in the pharmaceutical industry, joining Pfizer Global Research, Sandwich, UK in 1994, where he established a protein crystallography facility and then set up and headed up molecular informatics units in both Sandwich and in the USA. He joined UCB (Celltech) in 2002, leading computational and investigational chemistry teams and projects, with a particular focus on exploiting the synergies of antibody and small molecule therapeutics in inflammation.
He has been at the forefront of applying structural information to drug design and has a number of seminal publications and patents in this area. Of particular note are his contributions in establishing the practicality of fragment screening and introducing the concepts of ‘druggability’ and ‘ligand efficiency’; now used ubiquitously in medicinal chemistry. Colin’s interests and experience extend from pharmaceutical hit identification through to structural and computational analysis of the solid forms of active pharmaceutical ingredients.
Colin was Co-Director of the International School of Crystallography: Molecules to Medicines via Crystallography held in Erice, Italy in May 2008. He is a Fellow of the Royal Society of Chemistry and has contributed to academic research funding panels. He serves on the Editorial Boards of several journals.