CSD Solid Form Suite announced

The Cambridge Crystallographic Data Centre (CCDC) today announced the CSD Solid Form Suite to support pharmaceutical and agrochemical development. Using a knowledge-based approach the Solid Form Suite provides guidance and decision support for form screening and selection, enabling Quality by Design from an early stage.

"Solid Form Informatics is all about distilling the vast amount of data available in the Cambridge Structure Database (CSD) into targeted and actionable information regarding development routes, potential polymorphism and associated manufacturing risks", says Dr Colin Groom, Executive Director of the CCDC. "Adopting a Solid Form Informatics approach will help significantly reduce the risk of late stage failure that has been so costly to the industry."

Developed with a consortium of major pharmaceutical and agrochemical companies, the CSD Solid Form Suite includes predictive analytics methods that make use of the millions of intermolecular interactions stored in the CSD to inform on polymorphism and aid in coformer design. Statistical models are built from relevant structures in the CSD which encapsulate information regarding the environment of the functional groups, ensuring the prediction is specific to the target molecule. The CSD Solid Form Suite is designed to integrate neatly into a lab chemist's workflow and presents results in a form that supports form screening, selection and risk assessment.


According to a consortium member, "crystal polymorphism is a key risk factor for drug product manufacturing and performance and remains one of the major problems encountered in drug development. The CSD Solid Form Suite with its newly-developed Hydrogen Bond Propensity tool will help scientists to quantify the risk of polymorphism allowing them to make informed decisions on which crystalline form to develop. This tool, applied to known crystal structures and even 2D renditions of a molecular structure, is sure to advance the experimental screening and selection of drug crystal forms, the first step towards ensuring Quality is built by Design into drug products."

The CSD Solid Form Suite will be generally available at the end of November 2011 as part of the forthcoming 2012 release of the CSD System. For more information on the CSD Solid Form Suite, visit http://www.ccdc.cam.ac.uk/products/csd_solid_form_suite