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CSD Solid Form Suite: Knowledge based development and risk assessment
The CSD Solid Form Suite provides knowledge-based informatics tools for
improving effectiveness, quality and risk assessment in the development of
solid formulations of drugs, agrochemicals and molecular materials.
- Addressing development needs: Developed with a consortium of major
pharmaceutical and agrochemical companies, the CSD Solid Form Suite includes
predictive analytics methods that exploit the vast wealth of structural
knowledge in the Cambridge Structural Database (CSD). The CSD Solid Form Suite
is designed to integrate neatly into a lab chemist's workflow and presents
results in a form that supports form screening, selection and risk assessment.
- Polymorphism risk assessment: The new Hydrogen Bond Propensity tool helps
scientists to quantify the risk of polymorphism allowing them to make informed
decisions on which crystalline form to develop. This tool, applied to known
crystal structures and even 2D renditions of a molecular structure, can inform
the experimental screening and selection of drug crystal forms, the first step
towards ensuring Quality by Design.
- Analysis of solid forms: Scientists can readily quantify similarities and differences between polymorphs, hydrates and solvates, identify regions of structural similarity, and understand the strengths and weaknesses of structures by searching for extended functional group interaction motifs or general packing features, quickly and easily
The CSD Solid Form Suite is available as part of the 2012
release of the CSD System. Academic
institutions - access at no additional cost with the 2012 CSDS release. Industrial
organisations should contact admin@ccdc.cam.ac.uk.
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